Tilray Launches New High-CBD Cannabis Oil for Seizure Treatment in Canada

Tilray Launches New High-CBD Cannabis Oil for Seizure Treatment in Canada

Tilray Canada has launched its newest product, Tilray 2:100, a formulation of therapeutic cannabis oil containing a high concentration of cannabidiol (CBD), which may help treat Canadian patients with conditions like Dravet syndrome.

“We are excited to offer this highly concentrated CBD product to patients in Canada. We developed this product around a strong existing evidence base that CBD may be used in treating seizures when other anti-seizure drugs have failed,” Catherine Jacobson, PhD, director of Tilray’s clinical research program, said in a press release.

At a target concentration of 2 mg/ml of tetrahydrocannabinol (THC) and 100 mg/ml of CBD for a total cannabinoid amount of 80 mg of THC and 4,000 mg of CBD in each 40 ml bottle, Tilray 2:100 contains the highest concentration of plant-based CBD in a medical cannabis product available through Canada’s Access to Cannabis for Medical Purposes Regulations.

Tilray 2:100 contains the same target concentration of CBD and THC as an investigational treatment being tested in a current open-label Phase 1 clinical trial (NCT02983695) on pediatric epilepsy, taking place in Toronto.

Supported by Tilray, the trial is determining the tolerability and optimal dose of a CBD-rich cannabis extract (TIL-TC150) as an adjunct treatment in children with severe therapy-resistant epilepsy due to Dravet syndrome.

Tilray 2:100 is a whole-plant extract that uses CBD and is formulated with a coconut-derived carrier oil. The oral formulation comes ready to ingest directly.

The therapy will first be made available to children with treatment-resistant forms of epilepsy. As supply increases, the medical cannabis oil should become available to additional patients in Canada.

It will be sold at an introductory discount price, as well as in a compassionate pricing program based on financial need.

Although there is currently no cure for Dravet syndrome, some investigational treatments are being evaluated that can reduce the number of seizures and help make the condition more manageable.

One of these therapies is Epidiolex (GWP42003-P), an investigative, oral cannabidiol solution developed by GW Pharmaceuticals.

Like Tilray 2:100, Epidiolex is a non-psychoactive extract from the marijuana plant, meaning it does not have the mind-altering effects typical of THC, the main component of the plant that makes people “high.”

Scientists are still investigating how cannabidiol works to relieve epilepsy and hypothesize it may be due to its ability to interact with non-cannabinoid receptors in the brain – our brains have a natural endocannabinoid system with receptors that respond to CBD and THC.

In April 2018, a U.S. Food and Drug Administration advisory committee recommended approval of Epidiolex as a treatment for two rare forms of severe epilepsy — Dravet and Lennox-Gastaut syndromes.

An FDA approval would make Epidiolex the first-ever approved treatment for Dravet in the country, as well as the first plant-derived cannabidiol medicine of any kind approved for prescription use in the United States.

6 comments

  1. cannabis oil says:

    Marijuana proceeds to be the most hugely abused drug in The united states.
    The arguments for and in opposition to the legalization of cannabis
    maintain on to escalate. This piece is not intended to set the period for a legalization dialogue about
    marijuana. Alternatively, I want warning practitioners whose clients
    considerably less than their treatment examination favourable for marijuana.
    Cannabis use is even now forbidden by Federal law and
    individuals who self-medicate or abuse cannabis actually must not be approved controlled substances.

    Regrettably, many health professionals are usually faced
    with the predicament of no make any difference whether or not or not to prescribe
    managed substances to persons who drug exam constructive for
    marijuana. This is specially the condition in states that have modified issue restrictions to legalize
    marijuana. These improvements in point out regulation do not strengthen the Federal tips that medical professionals ought to abide by.
    As a former vocation DEA agent, I remind medical doctors
    that cannabis is even now an unlawful Agenda I
    managed compound with no accepted wellbeing care use in the U.S.

    The fact remains that all point out regulations have Federal
    oversight, as mentioned in the Supremacy Clause of
    the Construction. “The Supremacy Clause is a clause within of Report VI of the U.S. Constitution which dictates that federal law is the supreme legislation of the land. Beneath the doctrine of preemption, which is centered on the Supremacy Clause, federal legislation preempts place out regulation, even when the suggestions conflict.”(1)

    When a well being practitioner will develop into educated that a afflicted
    unique is using hashish, alternate techniques of solution need to be executed other than prescribing managed substances.
    Physicians really really should also get solutions to refer the affected individual for
    technique and cessation if any illegal drug use is exposed, such as marijuana.
    Health professionals require to also preserve in brain that the marijuana created now is considerably additional potent than the past and working with significant performance
    cannabis in conjunction with controlled substances is not risk-no cost
    for people.

    Is there such a make any difference as Meals and drug administration accredited wellbeing treatment marijuana?
    There are two Foods and drug administration accredited medication in the U.S.
    produced up of a synthetic analogue of THC (tetrahydrocannabinol), which is the principal chemical (cannabinoid) accountable for marijuana’s psychoactive final results.

    A synthetic version of THC is contained in the Fda authorised medicines Marinol (Software III) and Cesamet (Software II) which are proposed to cope with nausea for most cancers individuals likely by chemotherapy.
    Marinol is also approved to promote the urge for meals of most cancers and anorexia people (2).
    The Food stuff and drug administration is at this time overseeing trials getting performed on Epidiolex (three),
    a drug produced by GW Prescription drugs and designed
    to lower convulsive seizures in small types. The drug is produced up of cannabinoids from cannabis, referred to
    as cannabidiol or CBD, which does not include the psychoactive
    homes of normal cannabis and does not produce a top-quality.
    If this drug receives Food stuff and drug administration acceptance, it would make
    history at the moment staying the very initial permitted drug
    designed up of CBD in the U.S.

    Moreover, DEA has issued a special registration to a evaluation laboratory at the University of Mississippi to cultivate several
    strains of hashish for scientific trials (4). This
    look into will proceed, but as of this creating, ingesting or using tobacco cigarettes botanical cannabis or the hashish plant
    on your own is not federally accredited as an acknowledged wellness care cure in the
    U.S. Men and women who smoke or ingest hashish will have to have to be knowledgeable that they are breaking Federal regulation and could be prosecuted
    under Federal statutes. Also, physicians should to be
    tests for cannabis use and if detected, they ought to
    truly not prescribe controlled substances, no issue of their diagnosis and the patient’s
    indicators, as for every existing-day Federal statutes.

  2. Daneey says:

    The failure and dangers of current antiepileptic drugs can’t be overlooked. Topamax has caused metabolic acidosis. Lamicatal has caused severe rashes inside the mouth. Phenobarbital should be BANNED it so toxic and useless for seizures. Keppra can cause extreme headaches, although it does seem to be the best, least toxic anti epileptic drug (studies show if you take b vitamins with keppra it helps side effects, thus doctors should make this a priority when RX keppra). Depakote is linked to ataxia and deadly hyperammonia. ONFI should be banned. It’s a disgrace and fraud for epilepsy. Doesn’t work. Creates rapid drug tolerance since it’s basically a benzo in disguise. Actually increases seizures. It’s a disaster. The years and years people with epilepsy have suffered under these idiotic, ineffective drugs is pathetic and a disgrace. All these researchers. All this money. All this time and still a total flop. People are still suffering and having seizures, so yeah people, it’s time for cannabis CBD, which is more logical, humane and medically responsible than any other medicine that has been offered for people with epilepsy. Will it be a cure? Maybe not. But neither are any of the other anti epileptic drugs. Still, the issue here is side effects. The CBD is less harmful. Isn’t that the motto of medicine? DO NO HARM. CBD is the least harmful, most promising drug for people with epilepsy and nobody should be getting in the way of people having access to this helpful least harmful medicine. If they are, there’s something very wrong and diabolical going on, and hopefully karma will give them cancer and they will be denied the medicine they need because of self righteous selfish greedy controversy. (but hope they recover, not die, just get scared so they know how others suffer and feel when they don’t get access to researched based medicine known to help and do the least harm).

  3. Donna Taylor says:

    Would my daughter’s Dr. have access to prescribe Epidiolex to her as a treatment for her LGS where all other seizure drugs have failed? …right now she is on 3 seizure drugs but none will stop seizures.

  4. Charoul Lekx says:

    Can this product (2:100) be of benefit to an epileptic patient who has seizures not related to Dravet’s syndrome. My nephew is 21 and has been having partial complex seizures since he was 5. Medications and surgery have made little difference he’s having 10-15 seizures per day but we’re on our own when looking into CBD treatment so any help would be appreciated

  5. Tracee says:

    I’ve tried both the MJ and Hemp versions of CBD… the Hemp type worked way better! No one can legally sell or ship Hemp CBD in or to Canada without a Producer’s License and Health Canada approval though, but the company I found with certified pure, organic, patented and up front lab tested products, has this license and is soon expected to have this approval, likely the first to market. Look at the 🔗 as this is going to be very welcome news for us Canadians!

Leave a Comment

Your email address will not be published. Required fields are marked *