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Six months of treatment with the oral cannabidiol (CBD) solution Epidiolex among children and adolescents with Dravet syndrome or Lennox-Gastaut syndrome (LGS) was not associated with improvements in caregiver-reported quality of life or adaptive behaviors. That’s according to a small Korean study — though researchers noted that the…
Restoring the activity of Scn1a — the mouse variant of the gene that often is defective in humans with Dravet syndrome — suppressed seizures and normalized behavior in mice, even after symptom onset, a study showed. Notably, the improvements occurred in juvenile mice as well as in adult mice…
The first healthy volunteer has been dosed in a Phase 1 trial of BMB-101, Bright Minds Biosciences‘ investigational treatment for Dravet syndrome. BMB-101 is an orally available serotonergic medication, a class that modulate pathways associated with a signaling chemical called serotonin, that Bright Minds maintains could offer a…
Although the use of cannabidiol (CBD) is associated with reduced seizure frequency in children with Dravet syndrome, various cannabinoid-based products, including CBD, may be linked to adverse side effects in pediatric patients, a meta-analysis showed. Specifically, treatment with CBD may lead to an increased tendency for children to experience…
The 4th annual Dance for Dravet will be presented Oct. 14 in St. Louis, Missouri to support the research of the Dravet Syndrome Foundation (DSF) to find better therapies for this type of epilepsy which is characterized by prolonged seizures. The event, which will be held at the…
More than 70% of Dravet syndrome (DS) patients demonstrated a reduction in seizure frequency of at least 50% while treated with Fintepla (fenfluramine) as an add-on therapy for up to one year, according to an analysis of real-world data. The antiseizure response to this medication was similar in…
The blood levels of Fintepla (fenfluramine) are mostly within the lower range among treated children and adults with Dravet syndrome and other epileptic conditions, a study has found. Still, these levels were enough to achieve good seizure control in most Dravet patients, further supporting the therapy’s potent effects,…
Treatment with soticlestat significantly reduced seizure frequency for children with Dravet syndrome or Lennox-Gastaut syndrome (LGS), another childhood disorder that causes seizures, in a Phase 2 clinical trial called ELEKTRA. Trial results were in the study, “A phase 2, randomized, double-blind, placebo-controlled study to evaluate the…
Up to three years of treatment with the anti-seizure medication Fintepla (fenfluramine) did not result in any signs of valvular heart disease — damage to any of the heart’s four valves — or pulmonary arterial hypertension (PAH) in children with Dravet syndrome. That’s according to new results from an…
Treatment with low-dose aripiprazole — a newer class of antipsychotic medication — in combination with psychotherapy, and behavioral and occupational therapy, was found to lessen behavior, attention, and educational problems in a 6-year-old girl with Dravet syndrome, according to a case study. This case points out a potentially effective…
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