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Up to three years of treatment with Epidiolex in a clinical trial led to sustained reductions in seizure frequency — with the oral cannabidiol generally well-tolerated — in children and adults with seizures associated with tuberous sclerosis complex (TSC). That’s according to final data from an open-label extension…

Combining Xcopri (cenobamate) with existing antiseizure medications may significantly reduce the frequency of seizures in adults with Dravet syndrome, according to a report of four patients. The oral medication — marketed as Ontozry in Europe — reduced the frequency of seizures in all four adults by…

Not only do young people with Dravet syndrome show cognitive, developmental and behavioral differences compared with their normally developing peers, but these differences tend to become more pronounced in adolescence, according to a new study. “Our data indicate that the gap in adaptive function and overall intellectual development between…

STK-001, Stoke Therapeutics’ investigational therapy, continues to show promise in safely reducing seizures among children and adolescents with Dravet syndrome, according to new interim data from the ongoing Phase 1/2a MONARCH and ADMIRAL trials. “We are encouraged by the data from our ongoing studies of STK-001, which continue…

From sporting something purple to sharing graphics on social media, supporters are marking National Epilepsy Awareness Month (NEAM), observed each November to bring attention to epilepsy and its associated disorders, including Dravet syndrome. There are 65 million people around the world who live with the central nervous system…

Caregivers of children with Dravet syndrome in Sweden reported a number of factors, including fever, infections, physical activity, and tiredness could trigger a seizure in their child, according to a recent study. Families implemented a range of strategies to avoid these triggers, including avoidance of warm weather and…

Children and adolescents with Dravet syndrome with walking difficulties commonly experience impairments in functional mobility and greater restrictions in daily life activities, a study suggests. Its researchers recommend that physiotherapy be given patients to improve their gait, potentially allowing for better mobility in daily life. The study, “…

The U.S. Food and Drug Administration has expanded its approval of the anticonvulsant Diacomit (stiripentol) — when used as an adjunctive, or add-on therapy to Onfi (clobazam) — to help manage seizures in children with Dravet syndrome as young as 6 months of age. The infants must weigh…

There are close statistical associations between seizure frequency and the severity of other disease symptoms, such as language problems, in people with Dravet syndrome, a new study reports. “The significant relationships found between seizure measures and composite scores suggest that extended periods of seizure remission (whether expressed in terms of…

Japan’s Ministry of Health, Labour and Welfare has approved oral Fintepla (fenfluramine) as an add-on treatment for seizures associated with Dravet syndrome in adults and children 2 and older. The therapy is specifically indicated for patients whose seizures are not adequately controlled by other anti-seizure medications. The approval…