Posts by: Jose Marques Lopes, PhD

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Targeting a specific brain area called the reticular thalamic nucleus may be an effective treatment for non-convulsive seizures in children with Dravet syndrome, according to a mouse study. The study, ... Read more

December 20, 2018December 20, 2018

Symptom Severity Correlates with Distinct SCN1A Gene Mutation, Study Suggests

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Distinct mutations in the SCN1A gene are associated with different degrees of impairment in specific brain nerve cells as well as symptom severity in people with Dravet syndrome, according to a ... Read more

December 6, 2018December 6, 2018

Add-on Epidiolex Reduces Convulsive Seizures in Dravet Syndrome Patients, Phase 3 Trial Shows

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Add-on oral treatment with Epidiolex (cannabidiol) significantly lowered the frequency of convulsive seizures in patients with Dravet syndrome, according to topline results of a Phase 3 clinical trial. The ... Read more

September 19, 2018September 19, 2018

VNS Therapy Could Save Drug-resistant Epilepsy Patients Money Over 5 Years, Study Says

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Vagus nerve stimulation (VNS) therapy can lead to more than $77,000 in cost savings over five years for patients with drug-resistant epilepsy (DRE), compared to anti-epileptic treatments, according to new ... Read more

September 4, 2018September 4, 2018

Global Registry Launched on Vagus Nerve Stimulation Therapy for Patients with Drug-Resistant Epilepsy

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A new system of vagus nerve stimulation (VNS) therapy was implanted in the first patient with drug-resistant epilepsy, as part of a global registry launched by LivaNova to evaluate the treatment in ... Read more

April 19, 2018April 19, 2018

Antiepileptic Medications Increase Risk of Alzheimer’s and Dementia, Study Finds

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Continuous use of antiepileptic medications leads to an increased risk of Alzheimer’s disease and dementia, according to a recent study. These findings may have implications for the treatment of Dravet syndrome, epilepsy, ... Read more

April 10, 2018April 10, 2018

New Treatment Candidates Offer Hope for Dravet Syndrome Patients, Review Suggests

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Current first-line therapies for Dravet syndrome have limited effectiveness, but treatment candidates now undergoing clinical testing show significant promise, researchers suggest in a recent review. The study, “Treatment Strategies for ... Read more

March 29, 2018March 29, 2018

Stoke’s RNA-focused Therapy Generates Protein Lacking in Dravet Syndrome, Mouse Study Shows

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An RNA splicing technique that Stoke Therapeutics is developing led to the production of a protein that’s lacking in Dravet syndrome, a study in mice showed. Stoke discussed the approach at ... Read more

March 15, 2018March 15, 2018

Protein That Suppresses Seizures in Mice May Benefit Epilepsy Patients in Future

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Increased brain levels of a protein involved in inflammation were found to suppress seizures in mice, a finding that may have potential for the treatment of types of epilepsy, including ... Read more

Posts by: Jose Marques Lopes, PhD

Jose Marques Lopes, PhD

Targeting Specific Brain Region May Be Key in Treating Non-convulsive Seizures, Mouse Study Shows

Symptom Severity Correlates with Distinct SCN1A Gene Mutation, Study Suggests

Add-on Epidiolex Reduces Convulsive Seizures in Dravet Syndrome Patients, Phase 3 Trial Shows

VNS Therapy Could Save Drug-resistant Epilepsy Patients Money Over 5 Years, Study Says

Global Registry Launched on Vagus Nerve Stimulation Therapy for Patients with Drug-Resistant Epilepsy

Antiepileptic Medications Increase Risk of Alzheimer’s and Dementia, Study Finds

New Treatment Candidates Offer Hope for Dravet Syndrome Patients, Review Suggests

Stoke’s RNA-focused Therapy Generates Protein Lacking in Dravet Syndrome, Mouse Study Shows

Protein That Suppresses Seizures in Mice May Benefit Epilepsy Patients in Future

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